While I found Mass Effect's minigame to be absolutely devoid of fun and a chore, at least it lasts a maximum of 6 seconds and requires a minimum of effort.
And on a New Game+ you have enough omnigel to blast through every door in the game. Twice. After all, what else can you do with it...repair your invincible tank?
From worst to tolerable:
Oblivion - OOPS start all over again!
Bioshock - LOL PIPE DREAM
ThiefS & SplinterCell:CT - Find your controller's G-spot!
Deus Ex - Hold down mouse1 for 20 secondzzzzzzz
Mass Effect - LOL SIMON
System Shock 2 - LOL TIC TAC TOE
Thief 1&2 - Actually this made me feel like I was picking a lock